期刊
ANNALS OF NEUROLOGY
卷 68, 期 4, 页码 545-548出版社
WILEY
DOI: 10.1002/ana.22099
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资金
- National Institutes of Health [R01 AG026484]
- Alzheimer's Association [IIRG-06-26331]
- Harvard NeuroDiscovery Center (HNDC)
Advanced cerebrovascular beta-amyloid deposition (cerebral amyloid angiopathy, CAA) is associated with cerebral microbleeds, but the precise relationship between CAA burden and microbleeds is undefined. We used T2(star)-weighted magnetic resonance imaging (MRI) and noninvasive amyloid imaging with Pittsburgh Compound B (PiB) to analyze the spatial relationship between CAA and microbleeds. On coregistered positron emission tomography (PET) and MRI images, PiB retention was increased at microbleed sites compared to simulated control lesions (p = 0.002) and declined with increasing distance from the microbleed (p < 0.0001). These findings indicate that microbleeds occur preferentially in local regions of concentrated amyloid and support therapeutic strategies aimed at reducing vascular amyloid deposition. ANN NEUROL 2010;68:545-548
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