期刊
NATURE REVIEWS DRUG DISCOVERY
卷 5, 期 7, 页码 596-613出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrd2056
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资金
- NIA NIH HHS [R01 AG011085] Funding Source: Medline
Regulated protein turnover via the ubiquitin - proteasome system ( UPS) underlies a wide variety of signalling pathways, from cell-cycle control and transcription to development. Recent evidence that pharmacological inhibition of the proteasome can be efficacious in the treatment of human cancers has set the stage for attempts to selectively inhibit the activities of disease-specific components of the UPS. Here, we review recent advances linking UPS components with specific human diseases, most prominently cancer and neurodegenerative disorders, and emphasize potential sites of therapeutic intervention along the regulated protein-degradation pathway.
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