期刊
ANNALS OF NEUROLOGY
卷 65, 期 6, 页码 742-748出版社
WILEY
DOI: 10.1002/ana.21619
关键词
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资金
- Public Health Service [R01 NS 047029, R01 NS 041198, K24 NS 060950, R01 NS 057444, IK02NS054674]
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [K02NS054674, R01NS041198, R01NS047029, R01NS057444, K24NS060950] Funding Source: NIH RePORTER
The polyomavirus JC (JCV) is the causative agent of progressive multifocal leukoencephalopathy and of JCV granule cell neuronopathy. We present a human immunodeficiency virus-negative patient who experienced development of multiple cortical lesions, aphasia, and progressive cognitive decline after chemotherapy for non-small-cell lung cancer. Brain biopsy and cerebrospinal fluid polymerase chain reaction demonstrated JCV, and she had a rapidly fatal outcome. Postmortem analysis showed diffuse cortical lesions and areas of necrosis at the gray-white junction. Immunostaining showed a productive JCV infection of cortical pyramidal neurons, confirmed by electron microscopy, with limited demyelination. This novel gray matter syndrome expands the scope of JCV clinical presentation and pathogenesis.
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