期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 16, 期 13, 页码 3537-3540出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2006.03.088
关键词
pyrimido[4,5-d]pyrimidines; microwave irradiations; solvent-free conditions; glyoxylate imines; diaryl nitrones
Electron rich 6-[(dimethylamino)methylene] amino uracil 1, undergoes [4+2] cycloaddition reactions with various in situ generated glyoxylate imine and imine oxides 6 to provide novel pyrimido[4,5-d]pyrimidine derivatives of biological significance, after elimination of dimethylamine from the (1: 1) cycloadducts and oxidative aromatisation. This procedure provides a convenient method for the direct synthesis of pyrimido[4,5-d]pyrimidines in excellent yields when carried out in the solid state and under microwave irradiations. (c) 2006 Elsevier Ltd. All rights reserved.
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