期刊
ANNALS OF NEUROLOGY
卷 63, 期 6, 页码 798-802出版社
WILEY
DOI: 10.1002/ana.21383
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资金
- Intramural NIH HHS Funding Source: Medline
- NIA NIH HHS [R01 AG021918, N01 AG062106, R01 AG021918-01A1, AG-6-2103, AG-6-2106, N01 AG062103, AG021918, N01 AG062101, AG-6-2101] Funding Source: Medline
- NIDDK NIH HHS [DK069406, R01 DK069406, R01 DK069406-01A1] Funding Source: Medline
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK069406] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG021918, N01AG062101, N01AG062103, N01AG062106] Funding Source: NIH RePORTER
We determined whether serum cystatin C, a novel measure of kidney function that colocalizes with brain P-amyloid, is associated with cognition among 3,030 elders. Those with high cystatin C (n = 445; 15%) had worse baseline scores on Modified Mini-Mental State Examination or Digit Symbol Substitution Test (p <= 0.02) compared with those with intermediate/low level and 7 years greater decline (p <= 0.04). Incident cognitive impairment (decline >= 1.0 standard deviation) was greatest among those with high cystatin C (Modified Mini-Mental State Examination: 38 vs 25%; adjusted odds ratio, 1.92; 95% confidence interval, 1.37-2.69; Digit Symbol Substitution: 38 vs 26%; odds ratio, 1.54; 95% confidence interval, 1.10-2.15).
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