期刊
PEDIATRIC HEMATOLOGY AND ONCOLOGY
卷 23, 期 5, 页码 387-397出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/08880010600646662
关键词
acquired immune spherocytocis; hereditary spherocytosis; neonatal jaundice
As most of hereditary spherocytosis-affected individuals experience jaundice at birth, it seemed of interest to evaluate the proportion of hereditary spherocytosis in 402 severely jaundiced neonates with a bilirubinemia level prompting phototherapy. Red cell dehydration, a hallmark of spherocytosis whether constitutional or acquired, was demonstrated in 74 of them, among whom 23 disclosed a typical pattern of spherocytosis upon red cell deformability studies. Acquired spherocytosis of immune origin was diagnosed in 19/23 and hereditary spherocytosis in 4, making the proportion of hereditary spherocytosis-affected individuals among a severely jaundiced population of neonates amount to 1%, an incidence at least 30-fold that of the overall population.
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