期刊
CLINICAL LYMPHOMA & MYELOMA
卷 7, 期 1, 页码 26-29出版社
CIG MEDIA GROUP, LP
DOI: 10.3816/CLM.2006.n.035
关键词
deep vein thrombosis; dexamethasone; melphalan; peripheral neuropathy; prednisone
类别
Thalidomide has been demonstrated to be active as a first-line and salvage therapy in patients with multiple myeloma. Numerous studies over the past 8 years have shown it to induce high response rates and improve event-free survival in newly diagnosed patients as well as those with relapsed/refractory disease. Recent randomized clinical trials have demonstrated that thalidomide-based regimens are superior to conventional treatments in terms of response rates and event-free survival. However, few trials have demonstrated a survival benefit with thalidomide, indicating the need for further trials. This review will focus on recent trials of thalidomide in relapsed/refractory and newly diagnosed multiple myeloma and address some of the common adverse events associated with thalidomide treatment.
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