期刊
CELL CYCLE
卷 5, 期 13, 页码 1361-1365出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.5.13.2891
关键词
chromatin; histones; post-translational modifications; acetylation; euchromatin; transcription
类别
资金
- NIGMS NIH HHS [GM54096] Funding Source: Medline
How post-translational histone modifications regulate DNA utilization constitutes one of the central questions of chromatin biology. In studying the mechanistic role of histone H4-K16 acetylation, a mark with a functional role in maintaining transcriptionally permissive DNA domains or directly promoting gene transcription, we found that this acetylation both disrupts higher-order chromatin structure and changes the functional interaction of chromatin-associated proteins. The potential significance of this finding for in vivo chromatin structure, establishment of euchromatic domains, and promotion of gene transcription is examined.
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