期刊
MATHEMATICAL AND COMPUTER MODELLING
卷 44, 期 1-2, 页码 96-123出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.mcm.2004.07.021
关键词
angiogenesis; blood flow; capillary remodelling
In this paper, we present a theoretical investigation of the influence of blood flow through a tumour-induced capillary network, whereby the vascular architecture adapts as it grows to the associated haemodynamic forces resulting in what we describe as adaptive tumour-induced angiogenesis (ATIA). The network is generated in response to tumour angiogenic factors (TAFs), which are released from hypoxic cells within a solid tumour. We first describe a refined model for tumour-induced angiogenesis, which aims to describe the capillary growth process at the cellular level by explicitly taking into account the effects of matrix degrading enzymes and the local properties of the host tissue during endothelial cell migration. We then incorporate blood rheological properties into the formulation and investigate the influence of wall shear stress induced by the blood flow during dynamic vascular growth. We then go on to examine a number of feedback mechanisms affecting vascular resistance and network architecture. The mechanisms considered include those proposed by Pries and co-workers [A.R. Pries, T.W. Secomb, P. Gaehtgens, Structural adaptation and stability of microvascular networks: theory and simulation, Am. J. Physiol. Heart Circ. Physiol. 44 (1998) H349-H360; A.R. Pries, B. Reglin, T.W. Secomb, Structural adaptation of microvascular networks: functional roles of adaptative responses, Am. J. Physiol. Heart Circ. Physiol. 281 (2001) H1015-H1025; A.R. Pries, B. Reglin, T.W. Secomb, Structural adaptation of microvascular networks: roles of the pressure response, Hypertension 38 (2001) 1476-1479] and both haemodynamic (non-linear viscosity) and metabolic constraints are taken into account. Subsequent simulations of chemotherapeutic drug perfusion through the system show that vascular adaptation leads to a significant benefit in treatment delivery to the tumour. The results clearly demonstrate that the combined effects of network architecture and vessel compliance should be included in future models of angiogenesis if therapy protocols and treatment efficacy are to be adequately assessed. (c) 2005 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据