期刊
NATURE MEDICINE
卷 12, 期 7, 页码 852-855出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nm1437
关键词
-
资金
- NCI NIH HHS [R01CA098185, T32 CA009172] Funding Source: Medline
The sensitivity of conventional DNA sequencing in tumor biopsies is limited by stromal contamination and by genetic heterogeneity within the cancer. Here, we show that microreactor-based pyrosequencing can detect rare cancer-associated sequence variations by independent and parallel sampling of multiple representatives of a given DNA fragment. This technology can thereby facilitate accurate molecular diagnosis of heterogeneous cancer specimens and enable patient selection for targeted cancer therapies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据