期刊
BIOESSAYS
卷 28, 期 7, 页码 719-725出版社
WILEY
DOI: 10.1002/bies.20430
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资金
- NEI NIH HHS [EY13637] Funding Source: Medline
- NIA NIH HHS [AG14456] Funding Source: Medline
- NICHD NIH HHS [HD44096] Funding Source: Medline
Ribosomal RNA transcription was one of the first model systems for molecular characterization of a transcription regulatory mechanism and certainly one of the best studied in the widest range of organisms. In multicellular organisms, however, the issue of cell-type-specific regulation of rRNA transcription has not been well addressed. Here I propose that a systematic study of cell-type-specific regulation of rRNA transcription may reveal new regulatory mechanisms that have not been previously realized. Specifically, issues concerning the cell-type-specific requirement for rRNA production, the universality of Pol I transcription complex and the division of rDNA into regulatory subdomains are discussed.
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