期刊
ANNALS OF MEDICINE
卷 41, 期 8, 页码 599-607出版社
INFORMA HEALTHCARE
DOI: 10.1080/07853890903111018
关键词
Angioplasty; DES; myocardial infarction; paclitaxel; restenosis; stent thrombosis; stenting; titanium
资金
- Finnish Foundation for Cardiovascular Research, Helsinki, Finland
Background and aims. The aim of this study was to evaluate the long-term effects of the titanium-nitride-oxide-coated (TITANOX) stent and the paclitaxel-eluting stent (PES) in patients who had undergone a percutaneous coronary intervention for acute myocardial infarction (MI). Methods and results. The TITAX-AMI trial randomly assigned 425 patients with MI to receive either a TITANOX stent or a PES. The primary end-point was a composite of MI, target lesion revascularization, or death from cardiac causes. At 12 months, there was no significant difference between patients receiving TITANOX stent or PES in the rate of primary end-point (10.3% versus 12.8%, P = 0.5). After 2 years of follow-up, a significantly lower rate of primary end-point was observed in the TITANOX stent group compared with the PES group (11.2% versus 21.8%, HR 2.2, 95% confidence interval (CI) 1.3-3.8, P = 0.004). This difference was driven by a reduced rate of MI (5.1% versus 15.6%, P < 0.001) and cardiac death (0.9% versus 4.7%, P = 0.02) in favour of the TITANOX stent. Definite stent thrombosis occurred in 0.5% and 6.2% of the patients (P = 0.001), respectively. Conclusions. The implantation of a TITANOX stent resulted in better clinical outcome compared with a PES during 2 years of follow-up among patients treated for acute MI.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据