期刊
ANNALS OF MEDICINE
卷 40, 期 4, 页码 281-295出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/07853890801923753
关键词
bipolar disorder; major depressive disorder; mitochondria; mtDNA; schizophrenia
资金
- NIMH NIH HHS [R01 MH054844-05, P01 MH042251-16, MH42251, P50 MH060398, MH54844, P01 MH042251, P50 MH60398] Funding Source: Medline
- NATIONAL INSTITUTE OF MENTAL HEALTH [P01MH042251, P50MH060398, R01MH054844] Funding Source: NIH RePORTER
Recent findings of mitochondrial abnormalities in brains from subjects with neurological disorders have led to a renewed search for mitochondrial abnormalities in psychiatric disorders. A growing body of evidence suggests that there is mitochondrial dysfunction in schizophrenia, bipolar disorder, and major depressive disorder, including evidence from electron microscopy, imaging, gene expression, genotyping, and sequencing studies. Specific evidence of dysfunction such as increased common deletion and decreased gene expression in mitochondria in psychiatric illnesses suggests that direct examination of mitochondrial DNA from postmortem brain cells may provide further details of mitochondrial alterations in psychiatric disorders.
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