期刊
ANNALS OF MEDICINE
卷 40, 期 7, 页码 524-541出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/07853890802010709
关键词
cardiovascular epidemiology; genetic epidemiology; Mendelian randomization; observational studies
资金
- MRC [G0600705] Funding Source: UKRI
- Medical Research Council [G0600705] Funding Source: Medline
Observational studies have contributed in a major way to understanding modifiable determinants of cardiovascular disease risk, but several examples exist of factors that were identified in observational studies as potentially protecting against coronary heart disease, that in randomized controlled trials had no such effect. The likely reason for misleading findings from observational epidemiological studies is that associations are influenced by confounding, bias, and reverse causationwhere disease influences a risk factor, rather than vice versa. Mendelian randomization utilizes genetic variants that serve as proxy measures for modifiable risk factors to allow estimation of the causal influence of the modifiable risk factor in question. We present examples of the use of the Mendelian randomization approach and discuss both the limitations and potentials of this strategy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据