期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
卷 1763, 期 7, 页码 668-689出版社
ELSEVIER
DOI: 10.1016/j.bbamcr.2006.05.004
关键词
iron; iron regulatory protein; iron responsive element; translational control; RNA stability; protein degradation; iron-sulfur protein; phosphorylation; protein kinase C
资金
- NIDDK NIH HHS [R01 DK066600, DK 66600, R56 DK066600, DK 47219] Funding Source: Medline
- NIGMS NIH HHS [R01 GM045201-16, R01 GM045201, GM 45201] Funding Source: Medline
Both deficiencies and excesses of iron represent major public health problems throughout the world. Understanding the cellular and organismal processes controlling iron homeostasis is critical for identifying iron-related diseases and in advancing the clinical treatments for such disorders of iron metabolism. Iron regulatory proteins (IRPs) 1 and 2 are key regulators of vertebrate iron metabolism. These RNA binding proteins posttranscriptionally control the stability or translation of mRNAs encoding proteins involved in iron homeostasis thereby controlling the uptake, utilization, storage or export of iron. Recent evidence provides insight into bow IRPs selectively control the translation or stability of target mRNAs, how IRP RNA binding activity is controlled by iron-dependent and iron-independent effectors, and the pathological consequences of dysregulation of the IRP system. (c) 2006 Elsevier B.V. All rights reserved.
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