期刊
ACTA NEUROPATHOLOGICA
卷 112, 期 1, 页码 1-4出版社
SPRINGER
DOI: 10.1007/s00401-006-0072-x
关键词
Alzheimer's disease; amyloid; apolipoprotein AII; conformational disease; prion
资金
- NCRR NIH HHS [RR-00165, P51 RR000165] Funding Source: Medline
Koch's postulates were formulated in the late nineteenth century as guidelines for establishing that microbes cause specific diseases. Because the rules were developed for living agents-particularly bacteria-their applicability to inanimate pathogens such as viruses and infectious proteins has been problematic. The unorthodox mechanism by which prion diseases are transmitted, involving specific physicochemical characteristics of the protein as well as susceptibility traits of the host, has made these disorders refractory to analysis within the context of the original Koch's postulates. In addition, evidence is accumulating that other proteopathies, such as AA amyloidosis, apolipoprotein AII amyloidosis, and cerebral A beta amyloidosis, can be induced in vulnerable recipients by cognate proteinaceous agents. In light of the salient differences in the mode of disease-transmission by microbes and proteins, we propose modifications of Koch's postulates that will specifically accommodate presumed infectious proteins.
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