期刊
ORAL ONCOLOGY
卷 42, 期 6, 页码 625-631出版社
ELSEVIER
DOI: 10.1016/j.oraloncology.2005.11.002
关键词
oral tongue squamous cell carcinoma; immunohistochemistry; activated ERK1/2; cell cycle regulation; cell proliferation
We report an immunohistochemical. investigation of the expression of activated extracellular signal-regulated kinase (ERK1/2),and cyclin D1 protein in both oral tongue squamous cell carcinomas (OTSCCs) and normal tongue epithelium. The expression of Ki-67 labeling index (LI) was also examined in order to evaluate cell proliferation activity. The expression of activated ERK1/2, cyctin D1 protein and Ki-67 LI were significantly stronger in OTSCCs than in normal oral mucosa (P < 0.05). Both over-expression of activated ERK1/2 and positive expression of Ki-67 in OTSCCs were significantly associated with a moderately or poorly differentiated grade of carcinoma (P < 0.05). Cyclin D1 immunostaining showed statistically significant association with both lymph node metastasis (P < 0.05) and a tumor thickness > 5 mm (P < 0.05). Over-expression of activated ERK1/2 was positively correlated with cychn D1 protein expression (P < 0.05, r = 0.624) and cell proliferation - related indexes Ki-67 (P < 0.05, r = 0.723). Our results suggest that over-expression of activated ERK1/2 and cyctin D1 protein are involved in oral tongue carcinogenesis, and that activation of ERK1/2 might be related to cell cycle regulation and cell proliferation in OTSCCs. (c) 2005 Elsevier Ltd. All. rights reserved.
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