期刊
BIOLOGICAL & PHARMACEUTICAL BULLETIN
卷 29, 期 7, 页码 1504-1507出版社
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/bpb.29.1504
关键词
stilbene; topoisomerase; inhibitor
The inhibitory activity of 40 stilbene oligomers isolated from six plant species against topoisomerase II was evaluated, of which nine compounds showed a potent inhibitory effect, stronger than daunorubicin, a topoisomerase II inhibitor, used as an anti-cancer drug. The specificity of active stilbene oligomers on topoisomerase II was assessed by their effect on DNA restriction enzyme. In particular, specific inhibitory activity was observed in m-viniferin 13-O-beta-glucopryranoside (2) and hemsleyanol C (13).
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