期刊
FREE RADICAL BIOLOGY AND MEDICINE
卷 41, 期 1, 页码 19-28出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2006.01.037
关键词
antiviral host defense; nitric oxide
资金
- NCRR NIH HHS [M01 RR018390] Funding Source: Medline
- NHLBI NIH HHS [HL-68863, R01 HL060917, HL60917, R37 HL060917, K23 HL068863] Funding Source: Medline
- NIAID NIH HHS [AI70649] Funding Source: Medline
The airway mucosal epithelium is the first site of virus contact with the host, and the main site of infection and inflammation. Nitric oxide (NO) produced by the airway epithelium is vital to antiviral inflammatory and immune defense in the lung. Multiple mechanisms function coordinately to support high-level basal NO synthesis in healthy airway epithelium and further induction of NO synthesis in the infected airway of normal hosts. Hosts deficient in NO synthesis, such as those patients with cystic fibrosis, have impaired antiviral defense and may benefit from therapies to augment NO levels in the airways. (c) 2006 Elsevier Inc. All rights reserved.
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