期刊
DEVELOPMENTAL DYNAMICS
卷 235, 期 7, 页码 1908-1920出版社
WILEY
DOI: 10.1002/dvdy.20837
关键词
thrombospondin-1; angiogenesis; apoptosis; retinal vasculature; retinopathy of prematurity
资金
- NEI NIH HHS [EY13700] Funding Source: Medline
- NIDDK NIH HHS [DK67120] Funding Source: Medline
Thrombospondin-1 (TSP1) is an endogenous inhibitor of angiogenesis and induces endothelial cell (EC) apoptosis. To study the role TSP1 plays during vascular development and neovascularization, we assessed the effects of ectopic TSP1 expression in the lens on retinal vascularization in transgenic mice. The TSPI. over-expressing mice showed abnormalities in the development of retinal vasculature. There was a dramatic decrease in the density of superficial and deep vascular plexuses of the retina in transgenic mice. The retinal vessels in TSPI. transgenic mice also appeared nonuniform and abnormal in maturation. We detected an increase in the number of EC undergoing apoptosis, which was compensated, in part, by an increase in cell proliferation in retinal vasculature of TSPI. transgenic mice. The TSP1 transgenic mice also exhibited increased levels of vessel obliteration and a limited preretinal neovascularization during oxygen-induced ischemic retinopathy (0111). Our results indicate increased expression of TSPI. attenuates normal retinal vascularization and preretinal neovascularization during OIR. Therefore, modulation of TSP1 expression may provide an effective mechanism for regulation of ocular angiogenesis.
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