期刊
JOURNAL OF VIROLOGY
卷 80, 期 13, 页码 6706-6711出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00273-06
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- NCI NIH HHS [CA 50777] Funding Source: Medline
- NIAID NIH HHS [R41 AI051910, R42 AI051910, AI 51910] Funding Source: Medline
A significant difference in the recombination rates between human immunodeficiency virus type 1 (HIV-1) and the gammaretroviruses was previously reported, with the former being 10 to 100 times more recombinogenic. It is possible that preferential copackaging of homodimers in the case of gammaretroviruses, like murine leukemia virus (MLV), led to the underestimation of their rates of recombination. To reexamine the recombination rates for MLV, experiments were performed to control for nonrandom copackaging of viral RNA, and it was found that MLV and HIV-1 exhibit similar crossover rates. The implications for control of proviral ploidy and preferential recombination during minus-strand DNA synthesis are discussed.
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