期刊
JOURNAL OF NEUROSCIENCE
卷 26, 期 27, 页码 7139-7142出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.1821-06.2006
关键词
microfilament; tubulin; transport; granule; RNA trafficking; intracellular signaling; cytoskeleton
The targeting of mRNAs to neuronal dendrites is an important protein sorting mechanism. Recent studies have revealed that mRNAs are transported by molecular motors. The kinesin superfamily protein KIF5 transports mRNAs such as calcium/calmodulin-dependent kinase II alpha(CaMKII alpha) and Arc mRNAs along microtubules in large granules containing proteins involved in RNA transport, protein synthesis, RNA helicases, heterogeneous nuclear ribonucleoproteins ( hnRNPs), and RNA-associated proteins. This transport is fundamental to local protein synthesis and to the regulation of neuronal function.
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