期刊
JOURNAL OF NEUROSCIENCE
卷 26, 期 27, 页码 7151-7155出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.1790-06.2006
关键词
synaptic plasticity; CaMKII; FRMP; Rho GTPases; Fmr1 knock-out mice; synaptogenesis; learning and memory; metabotropic glutamate receptor; Rac1; SHANK-HOMER; dendritic spine; PSD-95
资金
- NIA NIH HHS [AG10154] Funding Source: Medline
- NICHD NIH HHS [HD07333] Funding Source: Medline
- NIMH NIH HHS [MH35321] Funding Source: Medline
Behavioral experiences can modulate neural networks through changes in synaptic morphology and number. In contrast, abnormal morphogenesis of dendritic spines is associated with cognitive impairment, as in Fragile X syndrome. Dendritic or synaptic protein synthesis could provide the specificity and speed necessary for spine morphogenesis. Here, we highlight locally translated proteins shown to affect synaptic morphology (e.g., Fragile X mental retardation protein).
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