期刊
MOLECULAR CELL
卷 23, 期 1, 页码 1-12出版社
CELL PRESS
DOI: 10.1016/j.molcel.2006.06.008
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资金
- NIA NIH HHS [R37 AG12859-11] Funding Source: Medline
- NIH HHS [DP1 OD000580-01] Funding Source: Medline
The developmental cell death in the nematode C. elegans is controlled by a simple and dedicated genetic program. This genetic program is evolutionarily conserved in higher organisms, including mammals. However, although mammalian homologs of C. elegans cell death gene products continue to regulate apoptosis, they are no longer dedicated regulators of cell death. On the other hand, multiple cellular noncell death-related mechanisms have been recruited to regulate cell death under different conditions. Such evidence suggests that evolution has led to an extensive integration of mammalian apoptosis machinery with multiple cellular physiological processes.
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