期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 71, 期 14, 页码 5357-5360出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo060018d
关键词
-
资金
- NCRR NIH HHS [P20 RR 16455-04] Funding Source: Medline
Berkeley Pit Lake is an abandoned open-pit copper mine filled with 30 billion gallons of acidic, metal-contaminated water. This harsh environment is proving to be a source of unusual microorganisms that produce novel bioactive metabolites. Bioassay-guided fractionation using signal transduction enzyme assays led to the isolation of the novel spiroketal, berkelic acid 1, and of the known gamma-pyrone, spiciferone A 4. Berkelic acid has shown selective, nanomolar activity against OVCAR-3, an ovarian cancer cell line in the National Cancer Institute cell line screen. The isolation and characterization of these compounds are reported here.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据