期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 203, 期 7, 页码 1817-1825出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20052495
关键词
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资金
- NCI NIH HHS [R37 CA038355, CA038355] Funding Source: Medline
- NIAID NIH HHS [R01 AI045809, R01 AI046710, AI046710, AI045809] Funding Source: Medline
- NIA NIH HHS [AG001743, P01 AG001743, R01 AG020186, AG020186] Funding Source: Medline
Most memory phenotype (MP) CD44(hi) CD8(+) cells are resting interleukin (IL)-15-dependent cells characterized by high expression of the IL-2/IL-15 receptor beta (CD122). However, some MP CD8(+) cells have a CD122(lo) phenotype and are IL-15 independent. Here, evidence is presented that the CD122(lo) subset of MP CD8(+) cells is controlled largely by major histocompatibility complex (MHC) class I molecules. Many of these cells display surface markers typical of recently activated T cells (CD62L(lo), CD69(hi), CD43(hi), and CD127(lo)) and show a high rate of background proliferation. Cells with this phenotype are highly enriched in common.. chain-deficient mice and absent from MHC-I-/- mice. Unlike CD122(hi) CD8+ cells, CD122lo MP CD8(+) cells survive poorly after transfer to MHC-I-/- hosts and cease to proliferate. Although distinctly different from typical antigen-specific memory cells, CD122lo MP CD8(+) cells closely resemble the antigen-dependent memory CD8(+) cells found in chronic viral infections.
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