期刊
BIOCHEMICAL JOURNAL
卷 397, 期 -, 页码 247-259出版社
PORTLAND PRESS LTD
DOI: 10.1042/BJ20060166
关键词
cellular response; cold-shock protein; cold-shock response; control of gene expression; sub-physiological temperature; yeast
资金
- Biotechnology and Biological Sciences Research Council [BB/C006569/1] Funding Source: Medline
- Biotechnology and Biological Sciences Research Council [BB/C006569/1] Funding Source: researchfish
Although the cold-shock response has now been studied in a number of different organisms for several decades, it is only in the last few years that we have begun to understand the molecular mechanisms that govern adaptation to cold stress. Notably, all organisms from prokaryotes to plants and higher eukaryotes respond to cold shock in a comparatively similar manner. The general response of cells to cold stress is the elite and rapid overexpression of a small group of proteins, the so-called CSPs (cold-shock proteins). The most well characterized CSP is CspA, the major CSP expressed in Escherichia coli upon temperature downshift. More recently, a number of reports have shown that exposing yeast or mammalian cells to sub-physiological temperatures (< 30 or < 37 degrees C respectively) invokes a co-ordinated cellular response involving modulation of transcription, translation, metabolism, the cell cycle and the cell cytoskeleton. In the present review, we summarize the regulation and role of coldshock genes and proteins in the adaptive response upon decreased temperature with particular reference to yeast and in vitro cultured mammalian cells. Finally, we present an integrated model for the co-ordinated responses required to maintain the viability and integrity of mammalian cells upon mild hypothermic cold shock.
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