期刊
CARDIOVASCULAR RESEARCH
卷 71, 期 2, 页码 195-207出版社
OXFORD UNIV PRESS
DOI: 10.1016/j.cardiores.2006.04.008
关键词
ROS; HIF; PHD; cytochromes; ion channels; oxygen-sensing
Current concepts of cellular oxygen-sensing include an isoform of the neutrophil NADPH oxidase, different electron carrier units of the mitochondrial electron transport chain (ETC), heme oxygenase-2 (HO-2), and a subfamily of 2-oxoglutarate dependent dioxygenases termed HIF (hypoxia inducible factor) prolyl hydroxylases (PHDs) and HIF asparagyl hydroxylase FIH-1 (factor-inhibiting HIF). Different oxygen sensitivities, cell-specific distribution and subcellular localization of specific oxygen-sensing cascades involving reactive oxygen species (ROS) as second messengers may help to tailor various adaptive responses according to differences in tissue oxygen availability. Herein, we propose an integrated model for these various oxygen-sensing mechanisms that very efficiently regulate HIF-alpha activity and plasma membrane potassium-channel (PMPC) conductivity. (c) 2006 European Society of Cardiology. Published by Elsevier B.V All rights reserved.
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