期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 16, 期 14, 页码 3697-3701出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2006.04.065
关键词
furopyrimidine; isocyanide; multicomponent reaction; N,N '-dimethylbarbituric acid; terephthaldialdehyde
A simple and efficient synthesis of 1,4-bis(furo[2,3-d]pyrimidine-2,4(1H,3H)-dione-5-yl)benzene derivatives was achieved via a one-pot three-component reaction of isocyanides, NN'-dimethylbarbituric acid, and terephthaldialdehyde in DMF at room temperature for 30 min. These improved reaction conditions allow the preparation of highly substituted furopyrimidinones in high yields and purity under mild reaction conditions. (c) 2006 Published by Elsevier Ltd.
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