期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 16, 期 14, 页码 3855-3858出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2006.04.029
关键词
natural product; peptide aldehyde; nerve growth factor (NGF); synthesis
资金
- NIGMS NIH HHS [R01 GM062120-10, R01 GM062120, GM062120] Funding Source: Medline
A combination of solid phase and solution phase synthetic methods have been used to complete the total synthesis of the neurotrophic lipopeptide aldehyde fellutamide B (2). The beta-hydroxy aliphatic tail was prepared by regioselective reductive opening of a cyclic sulfate, and later coupled to a solid phase resin. The synthetic compound was then examined in cytotoxicity and nerve growth factor (NGF) induction assays. A simplified analog of fellutamide B also showed activity. (c) 2006 Elsevier Ltd. All rights reserved.
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