期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 103, 期 29, 页码 10997-11002出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0602427103
关键词
migration; angiogenesis; reticulon; vascular remodeling; expression cloning
资金
- NINDS NIH HHS [R01 NS039962, R01 NS042304-08, R37 NS033020, R37 NS033020-15, R01 NS039962-10, R01 NS042304] Funding Source: Medline
Nogo isoforms (Nogo-A and -B) have been implicated in regulating neural and cardiovascular functions, such as cell spreading and chemotaxis. Unlike the loop domain (Nogo-66) found in all Nogo isoforms that can interact with a neural-specific Nogo-66 receptor, the receptor for the amino terminus of Nogo-B that mediates vascular function is unknown. Here, we identify a previously uncharacterized Nogo-B receptor specificforthe amino terminus of Nogo-B and show that Nogo-B receptor localizes with the ligand Nogo-B during VEGF and wound healing angiogenesis in vivo, mediates chemotaxis in a heterologous expression system and chemotaxis, and 3D tube formation in native endothelial cells. Thus, identification of this receptor may lead to the discovery of agonists or antagonists of this pathway to regulate vascular remodeling and angiogenesis.
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