期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 71, 期 15, 页码 5770-5773出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo060674d
关键词
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In the presence of onium salts, at 140-170 degrees C, methyl alkyl carbonates [1a-c, ROCO2Me, R) MeO(CH2) 2[O(CH2)(2)](n); n = 2-0, respectively] react with primary aromatic amines (XC6H4NH2, X = p-OMe, p-Me, H, p-Cl, p-CO2Me, o-Et, and 2,3-Me2C6H3NH2) to yield the corresponding N,N-dimethyl derivatives (ArNMe2) with high selectivity ( up to 96%) and good isolated yields (78-95%). Phosphonium salts ( e. g., Ph3PEtI and n-Bu4PBr) are particularly efficient catalysts. Overall, a solvent-free reaction is coupled with safe methylating agents (1a-c) made from nontoxic dimethyl carbonate.
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