期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 12, 期 22, 页码 5785-5789出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.200600026
关键词
asymmetric synthesis; chirality; kinetic resolution; noninear effects; racemic reagent
The reaction of a racemic reagent on a mixture of enantiomers with small ee (ee=enantiomeric excess) has been studied for amine acylation. A substantial asymmetric amplification could be realized, for example, from 67 to > 95.5 ee. The combination of asymmetric amplifications is subsequently discussed. Two sequential asymmetric amplifications, one using a racemic reagent and another using a positive nonlinear effect allowed us to start from 1.5 % ee and end with a large amount of a product of 97 % ee.
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