期刊
NEUROSCIENCE LETTERS
卷 402, 期 3, 页码 233-237出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2006.04.013
关键词
cardiovascular control; respiratory control; intermittent hypoxia; development; plasticity; neurogenesis
资金
- NHLBI NIH HHS [HL69932] Funding Source: Medline
- NINDS NIH HHS [F30 NS-48770] Funding Source: Medline
Early post-natal environmental exposures, including chronic intermittent hypoxia (CIH), may lead to Iona-term alterations in cardio-respiratory control, such as reductions in baroreflex sensitivity and acute hypoxic ventilatory responses in adult rats. Although the mechanisms underlying CIH-induced functional metaplasticity are unclear, anatomical alterations within selected brainstem nuclei may develop after CIH. To examine this issue, male rats were exposed to CIH (RAIH) or room air (RARA) for the first 30 days of life and were microinjected unilaterally in the right nodose ganglion with the neuronal tracer tetramethylrhodamine-dextran (TMR-D) to label brainstem neurons receiving vagal and glossopharyngeal projections. Substantial reductions in labeled afferents within the nucleus tractus solitarii (nTS) and significant increases in the total number of labeled neurons within the ventrolateral medulla (VLM), principally in the nucleus ambiguus (N-amb; P < 0.01) occurred in RAIH. Furthermore, 5-bromo-2'deoxyuridine labeling revealed enhanced neurogenesis within the N-amb in RAIH and could partially account for the increased neuronal population in N-amb. Thus, CIH-associated cardio-respiratory metaplasticity is accompanied by substantial structural changes within both the nTS and N-amb. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
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