期刊
SCIENCE
卷 313, 期 5786, 页码 526-530出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1128877
关键词
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资金
- NCI NIH HHS [R01 CA72074, R01 CA072074] Funding Source: Medline
- NHLBI NIH HHS [P50 HL067674, P50 HL67674] Funding Source: Medline
- NIAID NIH HHS [R01 AI023990, R37 AI23990] Funding Source: Medline
Snake or honeybee envenomation can cause substantial morbidity and mortality, and it has been proposed that the activation of mast cells by snake or insect venoms can contribute to these effects. We show, in contrast, that mast cells can significantly reduce snake-venom - induced pathology in mice, at least in part by releasing carboxypeptidase A and possibly other proteases, which can degrade venom components. Mast cells also significantly reduced the morbidity and mortality induced by honeybee venom. These findings identify a new biological function for mast cells in enhancing resistance to the morbidity and mortality induced by animal venoms.
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