期刊
PHYSIOLOGY & BEHAVIOR
卷 88, 期 4-5, 页码 398-403出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.physbeh.2006.04.014
关键词
anticipatory nausea; gaping; taste; aversion; context; rat; lithium chloride; saccharin; emetic; Delta(9)-THC; ondansetron
Chemotherapy patients report anticipatory nausea and vomiting upon re-exposure to the cues previously associated with the treatment. Although rats do not vomit, they display a distinctive gaping reaction when exposed to a toxin-paired flavored solution. Here we report that rats also display gaping reactions during exposure to a context previously paired with the illness-inducing effects of lithium chloride (Experiment 1). This gaping reaction is suppressed by pretreatment with the antiemetic agent, Delta(9)-tetrahydrocannabinol, but not ondansetron (Experiment 2). The finding that gaping is elicited by an illness-paired context confirms the proposal that an illness-paired context can evoke a conditioned state of nausea and supports the case of context-aversion as a rat model for anticipatory nausea. (c) 2006 Elsevier Inc. All rights reserved.
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