期刊
CURRENT OPINION IN IMMUNOLOGY
卷 18, 期 4, 页码 476-482出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2006.05.013
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资金
- NIGMS NIH HHS [R37 GM048071, R01 GM048071, GM-41514, R01 GM041514, R01 GM041514-21, GM-48071] Funding Source: Medline
The functioning of the immune system depends upon exquisitely choreographed interactions between its cellular constituents. Two-photon microscopy now enables us to visualize cell motility and cell-cell interactions deep within intact tissues and organs, both in explanted preparations and in vivo. Real-time immunoimaging techniques have illuminated the roles of random and chemokine-driven motility for cellular search strategies, the complex dynamics of cellular interactions, and the micro-anatomical localization and control of lymphocyte trafficking. Recently, advances have been made in these areas of research, as exemplified by studies investigating T cell-dendritic cell interactions, T cell-B cell interactions, and the regulation of lymphocyte egress from the lymph node.
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