期刊
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
卷 291, 期 2, 页码 R277-R284出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpregu.00729.2005
关键词
visceral perception; gender
类别
资金
- NCCIH NIH HHS [R24 AT-002681] Funding Source: Medline
- NIAMS NIH HHS [AR-41622] Funding Source: Medline
- NIDDK NIH HHS [DK-48351, P50 DK-64539] Funding Source: Medline
In irritable bowel syndrome (IBS) patients, the relationship between sex and sensitivity to visceral stimuli is incompletely understood. Our aim was to evaluate the effect of sex on perceptual responses to visceral stimulation in IBS. Fifty-eight IBS patients (mean age 42 +/- 1 yr; 34 men, 24 women) and 26 healthy controls (mean age 38 +/- 3 yr; 9 men, 17 women) underwent barostat-assisted distensions of the rectum and sigmoid colon. Rectal discomfort thresholds were measured using a randomized, phasic distension paradigm before and after repeated noxious sigmoid stimulation (SIG, 60-mmHg pulses). Sex had a significant effect on rectal discomfort thresholds. Women with IBS were the most sensitive ( lower thresholds [27 +/- 2.7 mmHg] and higher ratings), with significantly lower rectal discomfort thresholds compared with men with IBS (38 +/- 2.3 mmHg) and healthy women who were the least sensitive (41.9 +/- 3.2 mmHg; both P < 0.01). There were no significant differences in rectal discomfort thresholds between healthy men (34 +/- 4.3 mmHg) and men with IBS. Across both IBS and control groups, women demonstrated a significant lowering of discomfort thresholds after noxious sigmoid stimulation (P < 0.01), while men did not. Sex significantly influences perceptual sensitivity to rectosigmoid distension. Women show greater perceptual responses to this paradigm.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据