期刊
AMERICAN JOURNAL OF INDUSTRIAL MEDICINE
卷 49, 期 8, 页码 690-698出版社
WILEY
DOI: 10.1002/ajim.20345
关键词
biliary tract cancer; occupational exposure; textile industry; job-exposure matrix; female cohort
资金
- NCI NIH HHS [R01CA80180] Funding Source: Medline
- NIEHS NIH HHS [ES07262] Funding Source: Medline
Background Biliary tract cancer (BTC) is a relatively rare malignancy worldwide. Little is known about potential etiologic contributions of occupational exposures. Methods The associations between occupational exposures to textile dusts and chemicals and BTC are investigated in a cohort of 267,400 women textile workers in Shanghai, China. A nested case-cohort analysis of 162 BTC cases diagnosed during 1989-1998 was conducted with a reference subcohort of 3,188 workers. Exposures to workplace dusts and chemicals were reconstructed by linking complete work history data with a job-exposure matrix (JEM). Hazard ratios (HR) and dose-response trends were estimated by Cox proportional hazards modeling modified for case-cohort design. Results An elevated risk of >= 1-year employment in maintenance jobs (HR 2.92, 95% CI: 1.48, 5.73) with a significant trend by duration is observed. Excess risk was also found for >= 20 years exposure to metals (HR 2.50, 95% CI: 1.09, 5.72). Conclusions Long-term exposure to maintenance work and metals in the textile industry may have increased BTC risk in this population. Am. J. Ind. Med. 49:690-698, 2006. (c) 2006 Wiley-Liss, Inc.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据