期刊
NEOPLASIA
卷 8, 期 8, 页码 630-644出版社
ELSEVIER SCIENCE INC
DOI: 10.1593/neo.06334
关键词
p53; c-Myc; ubiquitylation; Yin and Yang; oncogenesis
类别
资金
- NCI NIH HHS [CA93614, R01 CA095441, R01 CA093614, CA095441, R01 CA079721] Funding Source: Medline
Protein ubiquitylation has been demonstrated to play a vital role not only in mediating protein turnover but also in modulating protein activity. The stability and activity of the tumor suppressor p53 and of the oncoprotein c-Myc are no exception. Both are regulated through independent ubiquitylation by several E3 ubiquitin ligases. Interestingly, p53 and c-Myc are functionally connected by some of these E3 enzymes and their regulator ARF, although these proteins play opposite roles in controlling cell growth and proliferation. The balance of this complex ubiquitylation network and its disruption during oncogenesis will be the topics of this review.
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