期刊
JOURNAL OF DENTAL RESEARCH
卷 85, 期 8, 页码 678-689出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/154405910608500801
关键词
dendritic cells; oral mucosa; periodontitis; Porphyromonas gingivalis; cytokines; T-cells
资金
- NIDCR NIH HHS [R01 DE014328, R01 DE14328, R01 DE014328-01] Funding Source: Medline
The mucosal lining of the respiratory and digestive systems contains the largest and most complex immune system in the body, but surprisingly little is known of the immune system that serves the oral mucosa. This review focuses on dendritic cells, particularly powerful arbiters of immunity, in response to antigens of microbial or tumor origin, but also of tolerance to self-antigens and commensal microbes. Although first discovered in 1868, the epidermal dendritic Langerhans cells remained enigmatic for over a century, until they were identified as the most peripheral outpost of the immune system. Investigators' ability to isolate, enrich, and culture dendritic cells has led to an explosion in the field. Presented herein is a review of dendritic cell history, ontogeny, function, and phenotype, and the role of different dendritic cell subsets in the oral mucosa and its diseases. Particular emphasis is placed on the mechanisms of recognition and capture of microbes by dendritic cells. Also emphasized is how dendritic cells may regulate immunity/tolerance in response to oral microbes.
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