期刊
SMALL
卷 2, 期 8-9, 页码 1090-1098出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.200600112
关键词
DNA; kinesin; microtubules; nanomanipulation
We have developed a technique to manipulate bifunctional DNA molecules: One end is thiolated to bind to a patterned gold surface and the other end is biotinylated to bind to a microtubule gliding over a kinesin-coated surface. We found that DNA molecules can be stretched and overstretched between the gold pads and the motile microtubules, and that they can form dynamic networks. This serves as a proof-of-principle that biological machineries can be used in vitro to accomplish the parallel formation of structured DNA templates that will have applications in biophysics and nanoelectronics.
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