期刊
VIROLOGY
卷 351, 期 2, 页码 404-419出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2006.03.023
关键词
HIV; restriction factors; cyclophilin; capsid; uncoating; retrovirus; reverse transcription; tropism
类别
资金
- NHLBI NIH HHS [HL 54785] Funding Source: Medline
- NIAID NIH HHS [AI 45405, AI 28691, AI 063987] Funding Source: Medline
In owl monkeys, a retrotransposition event replaced the gene encoding the retroviral restriction factor TRIM5 alpha with one encoding TRIMCyp, a fusion between the RING, B-box 2 and coiled-coil domains of TRIM5 and cyclophilin A. TRIMCyp restricts human immunodeficiency virus (HIV-1) infection by a mechanism dependent on the interaction of the cyclophilin A moiety and the HIV-1 capsid protein. Here, we show that infection by retroviruses other than HIV-1 can be restricted by TRIMCyp, providing an explanation for the evolutionary retention of the TRIMCyp gene in owl monkey lineages. The TRIMCyp-mediated block to HIV-1 infection occurs before the earliest step of reverse transcription. TRIMCyp-mediated restriction involves at least two functions: (1) capsid binding, which occurs most efficiently for trimeric TRIMCyp proteins that retain the coiled-coil and cyclophilin A domains, and (2) an effector function that depends upon the B-box 2 domain. (c) 2006 Elsevier Inc. All rights reserved.
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