期刊
GENES BRAIN AND BEHAVIOR
卷 5, 期 6, 页码 433-440出版社
WILEY
DOI: 10.1111/j.1601-183X.2005.00176.x
关键词
alpha 7; endophenotype; episodic memory; knockout; mice; nAChR; nicotine; nicotinic (7); schizophrenia
Patients with schizophrenia exhibit deficits in a range of cognitive functions, particularly working and episodic memory, which are thought to be core features of the disorder. Memory dysfunction in schizophrenia is familial and thus a promising endophenotype for genetic studies. Both human and animal studies suggest a role for the neural nicotinic acid receptor family in cognition and specifically the alpha 7-receptor subunit in schizophrenia and its endophenotypes. Consequently, we tested mice lacking the alpha 7 subunit of the neural nicotinic receptor (B6.129S7-Chrna7(tm1Bay)/J) in the delayed matching-to-place (DMP) task of the Morris water maze, a measure of working/episodic memory akin to human episodic memory. We report that a minor impairment in alpha 7 knockout mice was observed in the DMP task, with knockout mice taking longer to find the hidden platform than their wildtype controls. This suggests a role for the alpha 7 subunit in working/episodic memory and a potential role for the alpha 7 neural nicotinic receptor gene (CHRNA7) in schizophrenia and its endophenotypes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据