期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 63, 期 16, 页码 1819-1822出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-006-6170-z
关键词
endocytosis; heparan sulfate proteoglycan; HIV-TAT; polyarginine; protein transduction domain
资金
- NCI NIH HHS [R01 CA073808-09, CA73808, R01 CA073808] Funding Source: Medline
- NIGMS NIH HHS [GM44783] Funding Source: Medline
- PHS HHS [08349] Funding Source: Medline
Facilitating the entry of molecules into mammalian cells is of great interest to fields as diverse as cell biology and drug delivery. The discovery of natural protein transduction domains and the development of artificial ones, including polyarginine, provides a means to achieve this goal. Here, we comment on key chemical and biological aspects of cationic peptide internalization, including the physiological relevance of this process.
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