期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 177, 期 1-2, 页码 209-214出版社
ELSEVIER
DOI: 10.1016/j.jneuroim.2006.05.012
关键词
blood-brain barrier; spinal cord; endothelial cells; tight junctions
资金
- NIMH NIH HHS [R0-1-MH54718] Funding Source: Medline
The isolation and culture of spinal cord microvascular endothelial cells (SCMEC), which form the blood-spinal cord barrier (BSCB), is described. Though morphologically similar to brain microvacular endothelial cells (BMEC) that form the blood-brain barrier (BBB), SCMEC express reduced amounts of several prominent BBB proteins, including tight junction-associated proteins ZO-1 and occludin, adherens junction-associated proteins beta-catenin and VE-cadherin, and the efflux transporter P-glycoprotein. These distinguishing features may reflect more widespread differences between the BBB and BSCB that impact physiological and pathophysiological processes. (c) 2006 Elsevier B.V All rights reserved.
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