期刊
MYCOPATHOLOGIA
卷 162, 期 2, 页码 97-101出版社
SPRINGER
DOI: 10.1007/s11046-006-0041-x
关键词
chemotherapy treatment; chromoblastomycosis; cytokines; lymphoproliferation
类别
One of the most characteristic features of the chromoblastomycosis is its unresponsiveness to treatment. In order to analyzed whether during therapy could be observed a change of cellular immune response pattern, we evaluated the production of IL-10, TNF-alpha and IFN-gamma, as well as proliferation of peripheral blood mononuclear cell (PBMC) from patients in different periods of chemotherapy treatment. Our results showed that after 6 months of treatment cells from patients proliferated to fungal antigens and produced a significant level of IFN-gamma. However, after 1 year of treatment a low proliferation of T cells and production of IFN-gamma accompanied by an increase of IL-10 were observed when compared with 6 months of treatment.
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