期刊
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
卷 56, 期 2, 页码 86-90出版社
BLACKWELL PUBLISHING
DOI: 10.1111/j.1600-0897.2006.00388.x
关键词
bacterial vaginosis; heat shock protein; interleukin 1 receptor antagonist; nitric oxide; pregnancy
资金
- NCRR NIH HHS [M01RR0047] Funding Source: Medline
- NICHD NIH HHS [HD 35667, HD 41676] Funding Source: Medline
Problem To evaluate vaginal nitric oxide (NO) production in response to alterations in the vaginal microbial flora. Method of study Cervicovaginal lavage samples from 206 women at 18-22 weeks of gestation were tested for NO, interleukin-1 beta (IL-1 beta), IL-1 receptor antagonist (IL-1ra), tumor necrosis factor-alpha and the inducible 70 kDa heat shock protein (hsp70). Bacterial vaginosis (BV) was diagnosed based on gram staining of vaginal smears. Results and conclusions Elevated NO (> 2.14 mmol/L) was associated with a diagnosis of BV (38% versus 11%, P < 0.008) as well as an increased median vaginal IL-1ra concentration (72.5 ng/ml versus 36.6 ng/ml, P = 0.041). Elevated vaginal NO was also associated with vaginal hsp70 and this relationship was independent of BV status or IL-1ra concentrations (P < 0.026). We conclude that vaginal hsp70 release in response to abnormal vaginal microflora may trigger NO production in an attempt to minimize the pathological consequences of this altered milieu.
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