期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 177, 期 1-2, 页码 215-218出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2006.05.011
关键词
Substance P; Neuropeptide Y; innate immunity; antimicrobial activity
资金
- NIDCR NIH HHS [T32 DE014678, R01 DE014390] Funding Source: Medline
Infection and inflammation of mucosal tissue may induce the production of neuropeptides, specifically Substance P and Neuropeptide Y. Since these neuropeptides are similar to antimicrobial peptides in their amino acid composition, amphipathic design, cationic charge, and size, we wanted to determine if they had antimicrobial activity against a panel of common bacteria and oral microorganisms using the radial diffusion assay. Neuropeptide Y and Substance P had antimicrobial activity against E. coli (MIC 20.6 +/- 5.5 mu g/ml SEM and 71.5 +/- 15 SEM mu g/ml, respectively), but did not have activity against laboratory strains of Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Serratia marcescens (MIC > 500 mu g/ml) nor oral strains of Streptococcus mutans, Candida albicans, and Actinobacillus actinomycetemcomitans (MIC > 500 mu g/ml). While Substance P and Neuropeptide Y did not have direct antimicrobial activity against the microorganisms tested, they still may stimulate local epithelial cells to produce other innate immune factors like defensins and cathelicidins. However, this remains to be determined. (c) 2006 Elsevier B.V. All rights reserved.
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