期刊
EUROPEAN POLYMER JOURNAL
卷 42, 期 8, 页码 1775-1785出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.eurpolymj.2006.03.018
关键词
injectable; biodegradable; adhesive; polymerisation
资金
- Medical Research Council [MC_U117533887] Funding Source: researchfish
- MRC [MC_U117533887] Funding Source: UKRI
Fluid ABA triblock poly(lactide-co-propylene glycol-co-lactide)s with 7, 17 or 34 propylene glycol and 2, 4, or 8 lactic acid units in each B and A block, respectively, end capped with methacrylate groups were prepared and polymerisation rates upon blue light exposure for 60, 120 or 240 s using 0.5, 1 or 2 wt.% initiators determined. The shortest monomer formulation, with 0.5 wt.% initiators, was most promising as an injectable degradable adhesive for biomedical applications, achieving 96% polymerisation by 120 s after the start of 60 s illumination, forming then a semi-rigid polymer that in water released linearly with time poly(methacrylic-co-lactic) acid degradation products. Over 14 weeks, 2 turn thick specimens largely maintained their dimensions as water sorption balanced the 19 wt.% material loss. Raising initiator concentration or monomer length reduced polymerisation rate on the lower surface of samples. Increasing the number of lactic acid units in each A block from 2 to 8 also enhanced photocrosslinked polymer water sorption and increased average total mass loss to 60 wt.% over 14 weeks but acid product release rate decreased with time. Monomers produced with longer polypropylene glycol B blocks required longer periods of light exposure for full cure and the final polymers exhibited slower non-linear hydrolytic degradation. (c) 2006 Elsevier Ltd. All rights reserved.
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